SHMT1

Across TCGA cell cohorts, SHMT1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,370 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SHMT1-associated GO terms across cancer lineages are Glycine biosynthetic process, DTMP biosynthetic process, and Pyrimidine deoxyribonucleoside monophosphate biosynthetic process. Each is linked with SHMT1 in more than 19 cancer types. Because this analysis shows association rather than direction, both SHMT1-to-partner and partner-to-SHMT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Glycine biosynthetic process grouped by SHMT1-low versus SHMT1-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SHMT1→partner) and Y-score (partner→SHMT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Glycine biosynthetic process →	+0.259	+1.345	<.001	<.001	3	20
BONE	DTMP biosynthetic process →	+0.174	+1.114	.004	.003	3	19
BONE	Pyrimidine deoxyribonucleoside monophosphate biosynthetic process →	+0.174	+1.114	.004	.003	3	19
LIVER	'de novo' pyrimidine nucleobase biosynthetic process →	+0.180	+1.533	<.001	<.001	3	18
BONE	Purine nucleobase biosynthetic process →	+0.162	+1.806	<.001	<.001	3	18
LUNG_NSCLC_LUSC	Deoxyribonucleoside monophosphate biosynthetic process →	+0.180	+1.585	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,370 associations by consensus.

Glycine biosynthetic process by SHMT1 expression — BREAST

Explore this box plot interactively →