SHMT1

Across TCGA cell cohorts, SHMT1 mutation is significantly associated with the mutation status of many other genes, with 2,557 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SHMT1-associated genes across cancer lineages are SPECC1L, MFNG, and PLA2G3. Each is linked with SHMT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SHMT1-to-partner and partner-to-SHMT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPECC1L grouped by SHMT1-low versus SHMT1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHMT1→partner) and Y-score (partner→SHMT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SPECC1L →	+3.799	+5.217	<.001	<.001	1	1
LARGE_INTESTINE	MFNG →	+4.215	+3.874	<.001	<.001	1	1
LARGE_INTESTINE	PLA2G3 →	+2.630	+3.047	.005	.005	1	1
LARGE_INTESTINE	HIRA →	+2.407	+2.886	.008	.008	1	1
LARGE_INTESTINE	DEPDC5 →	+1.951	+3.015	.006	.006	1	1
LARGE_INTESTINE	TTC28 →	+2.340	+4.278	<.001	<.001	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,557 associations by consensus.

SPECC1L by SHMT1 expression — LARGE_INTESTINE

Explore this box plot interactively →