SHLD2

Across TCGA patient cohorts, SHLD2 protein abundance is significantly associated with the RNA expression of many other genes, with 614 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SHLD2-associated genes across cancer lineages are RANBP9, PRSS33, and SLC16A6. Each is linked with SHLD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SHLD2-to-partner and partner-to-SHLD2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SHLD2 versus RANBP9 in BRCA, with a Pearson correlation of -0.93.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHLD2→partner) and Y-score (partner→SHLD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RANBP9 →	-1.326	-0.903	.003	.009	3	1
BRCA	PRSS33 →	+0.113	+0.839	.009	.001	3	1
BRCA	SLC16A6 →	-4.119	-1.125	<.001	.007	3	1
BRCA	MRC2 →	-1.734	-0.990	.003	.005	3	1
BRCA	HCFC2 →	-1.255	-1.125	.009	.007	3	1
BRCA	PPM1G →	+0.780	+0.903	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 614 associations by consensus.

SHLD2 vs RANBP9 — BRCA

Explore this scatter interactively →