SHLD2

Across TCGA patient cohorts, SHLD2 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SHLD2-associated genes across cancer lineages are Ku80, p27_pT157, and Caspase-7-cleavedD198. Each is linked with SHLD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SHLD2-to-partner and partner-to-SHLD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by SHLD2-low versus SHLD2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHLD2→partner) and Y-score (partner→SHLD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.237	+1.495	.007	.034	3	2
UCEC	p27_pT157 →	-0.045	-1.415	.039	.046	3	2
UCEC	Caspase-7-cleavedD198 →	+0.779	+4.019	<.001	<.001	3	2
UCEC	4E-BP1 →	+0.295	+2.489	.003	.010	3	2
UCEC	Di-Ras3 →	-0.125	-3.308	.025	.009	3	2
SKCM	PDK1_pS241 →	+0.229	+3.017	.015	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

Ku80 by SHLD2 expression — UCEC

Explore this box plot interactively →