SHLD2

Across TCGA cell cohorts, SHLD2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,648 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SHLD2-associated GO terms across cancer lineages are Telomere maintenance in response to DNA damage, Lagging strand elongation, and Positive regulation of mitochondrial ATP synthesis coupled electron transport. Each is linked with SHLD2 in more than 15 cancer types. Because this analysis shows association rather than direction, both SHLD2-to-partner and partner-to-SHLD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Telomere maintenance in response to DNA damage grouped by SHLD2-low versus SHLD2-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SHLD2→partner) and Y-score (partner→SHLD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Telomere maintenance in response to DNA damage →	+0.097	+1.229	.001	<.001	3	16
BLOOD_Lymphoma	Lagging strand elongation →	+0.155	+0.913	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Positive regulation of mitochondrial ATP synthesis coupled electron transport →	+0.128	+0.927	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	DNA replication initiation →	+0.175	+1.197	<.001	<.001	3	13
SOFT_TISSUE	Regulation of protein acetylation →	+0.092	+0.820	.002	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Positive regulation of chromosome condensation →	+0.218	+1.062	<.001	.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,648 associations by consensus.

Telomere maintenance in response to DNA damage by SHLD2 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →