SHLD1

Across TCGA cell cohorts, SHLD1 protein abundance is significantly associated with the RNA expression of many other genes, with 1,490 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible SHLD1-associated genes across cancer lineages are SYTL2, IQCN, and PAK1IP1. Each is linked with SHLD1 in more than 3 cancer types. Because this analysis shows association rather than direction, both SHLD1-to-partner and partner-to-SHLD1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SHLD1 versus SYTL2 in LUNG_NSCLC_LUAD, with a Pearson correlation of -0.53.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHLD1→partner) and Y-score (partner→SHLD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SYTL2 →	-1.153	-0.608	.002	<.001	3	4
LUNG_SCLC	IQCN →	-1.493	-2.082	.004	.009	3	4
BLOOD_Myeloma	PAK1IP1 →	+0.512	+0.794	.002	.002	3	4
BLOOD_Leukemia	RPL21 →	+0.620	+0.830	.005	.005	3	4
CNS	NDUFA2 →	-0.568	-1.148	.006	.007	3	3
CNS	LILRB3 →	+0.308	+0.889	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,490 associations by consensus.

SHLD1 vs SYTL2 — LUNG_NSCLC_LUAD

Explore this scatter interactively →