SHISAL2A

Across TCGA pan-cancer cohorts, SHISAL2A Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated SHISAL2A data layer compared with 25 for mass-spec protein.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher SHISAL2A Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SHISAL2A expression acts as an unfavorable survival marker.

STAD and LUAD are the cancer types where SHISAL2A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	OS	Median	All	0.216	0.689	<.001	30	view →
LUAD	DFS	Median	II,III,IV	0.098	0.651	.001	3	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

SHISAL2A–STAD (OS)

Open the STAD breakdown →