SHISAL2A

Across TCGA patient cohorts, SHISAL2A mutation is significantly associated with the RNA expression of many other genes, with 412 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SHISAL2A-associated genes across cancer lineages are MTATP6P7, MMS19, and ATP5MC1. Each is linked with SHISAL2A in more than 1 cancer types. Because this analysis shows association rather than direction, both SHISAL2A-to-partner and partner-to-SHISAL2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTATP6P7 grouped by SHISAL2A-low versus SHISAL2A-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHISAL2A→partner) and Y-score (partner→SHISAL2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MTATP6P7 →	+0.114	+5.309	<.001	.003	3	2
UCEC	MMS19 →	+0.517	+3.201	.005	.009	3	1
UCEC	ATP5MC1 →	+0.524	+3.210	.007	.009	3	1
UCEC	AMFR →	+0.676	+3.502	.002	.002	3	1
UCEC	ABHD18 →	+0.461	+3.202	.006	.009	3	1
UCEC	TEX264 →	+0.454	+3.369	.005	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 412 associations by consensus.

MTATP6P7 by SHISAL2A expression — LUSC

Explore this box plot interactively →