SHISAL2A

Across TCGA patient cohorts, SHISAL2A mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SHISAL2A-associated genes across cancer lineages are JNK_pT183_Y185, ATM, and Ku80. Each is linked with SHISAL2A in more than 1 cancer types. Because this analysis shows association rather than direction, both SHISAL2A-to-partner and partner-to-SHISAL2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by SHISAL2A-low versus SHISAL2A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHISAL2A→partner) and Y-score (partner→SHISAL2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.218	-3.000	.018	.036	3	1
UCEC	ATM →	-0.665	-3.169	.007	.020	3	1
UCEC	Ku80 →	+0.334	+3.183	.009	.010	1	1
UCEC	Rab25 →	-0.660	-3.169	<.001	.020	1	1
UCEC	VHL →	-1.171	-3.169	.001	.020	1	1
UCEC	Cyclin-B1 →	+0.752	+3.169	.014	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

JNK_pT183_Y185 by SHISAL2A expression — UCEC

Explore this box plot interactively →