SHISAL1

Across TCGA patient cohorts, SHISAL1 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SHISAL1-associated genes across cancer lineages are PCNA, 4E-BP1, and C-Raf. Each is linked with SHISAL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SHISAL1-to-partner and partner-to-SHISAL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by SHISAL1-low versus SHISAL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHISAL1→partner) and Y-score (partner→SHISAL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.213	+2.115	.024	.019	3	3
UCEC	4E-BP1 →	+0.265	+2.999	.025	.035	3	2
COAD	C-Raf →	+0.194	+2.841	.010	.033	3	2
SKCM	eIF4E →	+0.235	+3.169	.010	.018	2	2
SKCM	Bak →	+0.229	+3.012	.045	.018	3	1
SKCM	DJ-1 →	+0.222	+2.186	.018	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

PCNA by SHISAL1 expression — UCEC

Explore this box plot interactively →