SHISA9

Across TCGA patient cohorts, SHISA9 protein abundance is significantly associated with the RNA expression of many other genes, with 2,757 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SHISA9-associated genes across cancer lineages are PRODH, SEZ6L, and SEPTIN3. Each is linked with SHISA9 in more than 1 cancer types. Because this analysis shows association rather than direction, both SHISA9-to-partner and partner-to-SHISA9 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SHISA9 versus PRODH in GBM, with a Pearson correlation of 0.47.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHISA9→partner) and Y-score (partner→SHISA9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PRODH →	+0.867	+0.589	<.001	<.001	3	1
GBM	SEZ6L →	+1.705	+0.579	<.001	<.001	3	1
GBM	SEPTIN3 →	+1.207	+0.718	<.001	<.001	3	1
GBM	NEFH →	+0.957	+0.452	<.001	<.001	3	1
GBM	RASD2 →	+0.639	+0.652	<.001	<.001	3	1
GBM	SYNGR1 →	+0.818	+0.622	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,757 associations by consensus.

SHISA9 vs PRODH — GBM

Explore this scatter interactively →