SHISA9

Across TCGA patient cohorts, SHISA9 mutation is significantly associated with the RNA expression of many other genes, with 1,997 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SHISA9-associated genes across cancer lineages are RPL7P43, SPTLC1P5, and MTCYBP7. Each is linked with SHISA9 in more than 1 cancer types. Because this analysis shows association rather than direction, both SHISA9-to-partner and partner-to-SHISA9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL7P43 grouped by SHISA9-low versus SHISA9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHISA9→partner) and Y-score (partner→SHISA9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RPL7P43 →	+0.110	+2.492	<.001	<.001	3	2
COAD	SPTLC1P5 →	+0.377	+4.246	<.001	<.001	3	2
COAD	MTCYBP7 →	+0.071	+4.251	<.001	.008	3	2
COAD	MTND1P26 →	+0.506	+4.251	<.001	.008	3	2
BRCA	MIR6826 →	+0.373	+3.586	.003	.002	3	1
CESC	SCP2D1-AS1 →	+0.083	+4.455	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,997 associations by consensus.

RPL7P43 by SHISA9 expression — UCEC

Explore this box plot interactively →