SHISA9

Across TCGA patient cohorts, SHISA9 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SHISA9-associated genes across cancer lineages are Notch1, Cyclin-E2, and IRS1. Each is linked with SHISA9 in more than 1 cancer types. Because this analysis shows association rather than direction, both SHISA9-to-partner and partner-to-SHISA9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by SHISA9-low versus SHISA9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHISA9→partner) and Y-score (partner→SHISA9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.149	+3.183	.012	.009	3	2
UCEC	Cyclin-E2 →	+0.166	+1.594	.020	.042	3	2
UCEC	IRS1 →	+0.273	+2.222	.001	.011	3	1
UCEC	Ku80 →	+0.234	+1.713	.019	.027	3	1
UCEC	p27_pT198 →	+0.110	+2.459	.015	.019	3	1
UCEC	Annexin_VII →	-0.162	-2.222	.006	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Notch1 by SHISA9 expression — UCEC

Explore this box plot interactively →