SHISA9

Across TCGA cell cohorts, SHISA9 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,863 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible SHISA9-associated GO terms across cancer lineages are Ruffle assembly, Insulin receptor signaling pathway, and Zymosterol metabolic process. Each is linked with SHISA9 in more than 4 cancer types. Because this analysis shows association rather than direction, both SHISA9-to-partner and partner-to-SHISA9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ruffle assembly grouped by SHISA9-low versus SHISA9-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SHISA9→partner) and Y-score (partner→SHISA9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Ruffle assembly →	+0.134	+1.648	<.001	<.001	3	5
SOFT_TISSUE	Insulin receptor signaling pathway →	+0.075	+1.466	<.001	.005	3	5
OVARY	Zymosterol metabolic process →	+0.090	+1.476	.009	.001	3	5
OVARY	Zymosterol biosynthetic process →	+0.090	+1.476	.009	.001	3	5
KIDNEY	Epithelial cell-cell adhesion →	+0.210	+3.394	<.001	<.001	3	4
KIDNEY	Regulation of hippo signaling →	+0.074	+2.650	.003	.002	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,863 associations by consensus.

Ruffle assembly by SHISA9 expression — BREAST

Explore this box plot interactively →