Across TCGA patient cohorts, SHISA7 protein abundance is significantly associated with the RNA expression of many other genes, with 2,231 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SHISA7-associated genes across cancer lineages are SEZ6L, SOX10, and SEPTIN3. Each is linked with SHISA7 in more than 1 cancer types. Because this analysis shows association rather than direction, both SHISA7-to-partner and partner-to-SHISA7 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHISA7→partner) and Y-score (partner→SHISA7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SEZ6L →	+1.078	+0.453	.004	.001	3	1
GBM	SOX10 →	+1.283	+0.573	<.001	<.001	3	1
GBM	SEPTIN3 →	+0.900	+0.577	<.001	<.001	3	1
GBM	NEFH →	+1.076	+0.611	<.001	<.001	3	1
GBM	SYNGR1 →	+0.720	+0.526	<.001	.001	3	1
GBM	PNPLA5 →	+0.311	+0.834	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,231 associations by consensus.

Exploration

SHISA7 survival (RNA) · tumor vs normal (RNA) · all SHISA7 data types