Across TCGA patient cohorts, SHISA7 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SHISA7-associated genes across cancer lineages are EGFR_pY1068, eIF4E, and A-Raf_pS299. Each is linked with SHISA7 in more than 1 cancer types. Because this analysis shows association rather than direction, both SHISA7-to-partner and partner-to-SHISA7 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHISA7→partner) and Y-score (partner→SHISA7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.273	-2.321	.008	.006	3	1
UCEC	eIF4E →	+0.239	+3.335	.005	.005	3	1
UCEC	A-Raf_pS299 →	-0.155	-2.700	.001	.006	3	1
UCEC	JNK2 →	+0.303	+2.196	<.001	.032	3	1
UCEC	MEK1 →	+0.475	+3.807	.001	<.001	3	1
UCEC	Notch1 →	+0.123	+1.807	.034	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Exploration

SHISA7 survival (RNA) · tumor vs normal (RNA) · all SHISA7 data types