Across TCGA pan-cancer cohorts, SHISA6 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated SHISA6 data layer compared with 23 for mass-spec protein.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher SHISA6 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SHISA6 expression acts as an unfavorable survival marker.

READ and UCEC are the cancer types where SHISA6 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	OS	Median	II,III,IV	0.287	0.816	.001	15	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: SHISA6 tumor-vs-normal RNA expression · all SHISA6 data types