Across TCGA patient cohorts, SHISA6 protein abundance is significantly associated with the RNA expression of many other genes, with 3,742 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SHISA6-associated genes across cancer lineages are YPEL1, SNRPD3, and PRODH. Each is linked with SHISA6 in more than 1 cancer types. Because this analysis shows association rather than direction, both SHISA6-to-partner and partner-to-SHISA6 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHISA6→partner) and Y-score (partner→SHISA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	YPEL1 →	+0.800	+0.960	<.001	<.001	3	1
GBM	SNRPD3 →	+0.434	+0.654	<.001	<.001	3	1
GBM	PRODH →	+0.788	+0.723	.006	.001	3	1
GBM	GRK3 →	+0.550	+0.575	<.001	.008	3	1
GBM	SEZ6L →	+2.272	+0.892	<.001	<.001	3	1
GBM	SRRD →	+0.385	+0.703	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,742 associations by consensus.

Exploration

SHISA6 survival (RNA) · tumor vs normal (RNA) · all SHISA6 data types