Across TCGA patient cohorts, SHISA6 protein abundance is significantly associated with the protein abundance of many other proteins, with 4,003 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SHISA6-associated proteins across cancer lineages are PPP3R1, SHISA6_S241, and SHISA6_S391. Each is linked with SHISA6 in more than 1 cancer types. Because this analysis shows association rather than direction, both SHISA6-to-partner and partner-to-SHISA6 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SHISA6→partner) and Y-score (partner→SHISA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PPP3R1 →	+0.893	+0.928	<.001	<.001	3	2
GBM	SHISA6_S241 →	+0.676	+0.588	<.001	<.001	3	1
GBM	SHISA6_S391 →	+1.539	+1.089	<.001	<.001	3	1
GBM	SHISA7 →	+0.586	+0.606	<.001	.001	3	1
GBM	SHISA9_S337 →	+1.089	+0.649	<.001	<.001	3	1
GBM	SIPA1_S314 →	-0.419	-0.840	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,003 associations by consensus.

Exploration

SHISA6 survival (RNA) · tumor vs normal (RNA) · all SHISA6 data types