Across TCGA patient cohorts, SHISA6 mutation is significantly associated with the RNA expression of many other genes, with 1,850 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SHISA6-associated genes across cancer lineages are IGHV2-70, LIN7C, and TMEM263. Each is linked with SHISA6 in more than 1 cancer types. Because this analysis shows association rather than direction, both SHISA6-to-partner and partner-to-SHISA6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHISA6→partner) and Y-score (partner→SHISA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGHV2-70 →	+1.759	+2.807	<.001	<.001	3	2
UCEC	LIN7C →	+0.567	+2.593	.001	<.001	3	2
UCEC	TMEM263 →	+0.529	+2.423	.002	.001	3	2
UCEC	SLAMF8 →	+0.685	+1.925	.004	.005	3	2
UCEC	CD3G →	+0.558	+2.362	.001	.003	3	2
UCEC	HK3 →	+0.559	+3.354	.005	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,850 associations by consensus.

Exploration

SHISA6 survival (RNA) · tumor vs normal (RNA) · all SHISA6 data types