Across TCGA patient cohorts, SHISA6 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SHISA6-associated genes across cancer lineages are EGFR_pY1068, EGFR, and eIF4G. Each is linked with SHISA6 in more than 1 cancer types. Because this analysis shows association rather than direction, both SHISA6-to-partner and partner-to-SHISA6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHISA6→partner) and Y-score (partner→SHISA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.200	-1.584	.042	.036	3	1
UCEC	EGFR →	-0.162	-3.143	.009	.018	3	1
UCEC	eIF4G →	+0.361	+3.700	.002	.001	3	1
UCEC	ACC1 →	+0.347	+1.750	.015	.049	3	1
UCEC	JNK_pT183_Y185 →	-0.196	-2.489	.003	.002	3	1
UCEC	Ku80 →	+0.266	+1.710	.004	.025	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Exploration

SHISA6 survival (RNA) · tumor vs normal (RNA) · all SHISA6 data types