Across TCGA cell cohorts, SHISA6 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,561 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SHISA6-associated GO terms across cancer lineages are Regulation of plasminogen activation, Negative regulation of protein maturation, and Microtubule-based transport. Each is linked with SHISA6 in more than 2 cancer types. Because this analysis shows association rather than direction, both SHISA6-to-partner and partner-to-SHISA6 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SHISA6→partner) and Y-score (partner→SHISA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of plasminogen activation →	-0.309	-2.964	<.001	<.001	3	3
BONE	Negative regulation of protein maturation →	-0.171	-1.631	<.001	.005	3	3
BONE	Microtubule-based transport →	+0.044	+2.605	<.001	<.001	3	3
BONE	Regulation of focal adhesion assembly →	-0.169	-1.787	<.001	.001	3	3
BONE	Positive regulation of mononuclear cell migration →	-0.157	-2.070	<.001	<.001	3	3
BONE	Regulation of cell-substrate junction assembly →	-0.169	-1.787	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,561 associations by consensus.

Exploration

SHISA6 survival (RNA) · tumor vs normal (RNA) · all SHISA6 data types