Across TCGA pan-cancer cohorts, SHISA4 Mutation is linked to patient survival in 1 of 34 cancer types, making it a survival-associated SHISA4 data layer compared with 27 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher SHISA4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SHISA4 expression acts as an unfavorable survival marker.

LUSC are the cancer types where SHISA4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Median	All	0.011	0.819	<.001	12	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

Exploration

Same gene, other analysis: SHISA4 tumor-vs-normal RNA expression · all SHISA4 data types