Across TCGA pan-cancer cohorts, SHISA4 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated SHISA4 data layer compared with 27 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher SHISA4 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated SHISA4 expression acts as an unfavorable survival marker, although some lineages such as LUAD and GBM show a favorable association.

LUAD, LSCC, and GBM are the cancer types where SHISA4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	All	0.978	0.275	.003	34	view →
LSCC	OS	Median	II,III,IV	0.552	1.000	.048	2	view →
GBM	OS	Median	All	0.630	0.450	.040	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: SHISA4 tumor-vs-normal RNA expression · all SHISA4 data types