Across TCGA patient cohorts, SHISA4 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SHISA4-associated genes across cancer lineages are GSK3-a-b, Smad3, and Src_pY416. Each is linked with SHISA4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SHISA4-to-partner and partner-to-SHISA4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHISA4→partner) and Y-score (partner→SHISA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GSK3-a-b →	+0.170	+3.000	.029	.037	3	1
UCEC	Smad3 →	+0.222	+3.000	.010	.036	3	1
UCEC	Src_pY416 →	-0.311	-2.986	.025	.037	3	1
UCEC	c-Met_pY1235 →	+0.104	+2.817	.015	.036	3	1
UCEC	DJ-1 →	+0.225	+3.000	.019	.037	3	1
UCEC	ER-alpha →	-1.086	-3.000	.022	.037	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

Exploration

SHISA4 survival (RNA) · tumor vs normal (RNA) · all SHISA4 data types