SHISA3

Across TCGA patient cohorts, SHISA3 RNA expression is significantly associated with the protein abundance of many other proteins, with 10,674 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SHISA3-associated proteins across cancer lineages are ITIH1, SLIT3, and AFM. Each is linked with SHISA3 in more than 4 cancer types. Because this analysis shows association rather than direction, both SHISA3-to-partner and partner-to-SHISA3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SHISA3 versus ITIH1 in CCRCC, with a Pearson correlation of 0.41.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SHISA3→partner) and Y-score (partner→SHISA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ITIH1 →	+0.745	+1.073	<.001	<.001	3	5
LSCC	SLIT3 →	+0.477	+0.601	<.001	.002	3	4
BRCA	AFM →	+0.653	+0.314	<.001	<.001	3	4
PDAC	F2 →	+0.476	+0.495	<.001	<.001	3	4
OV	MRPL17 →	-0.400	-0.636	<.001	.008	3	4
CCRCC	PYGM →	+0.636	+1.093	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,674 associations by consensus.

SHISA3 vs ITIH1 — CCRCC

Explore this scatter interactively →