SHISA3

Across TCGA patient cohorts, SHISA3 protein abundance is significantly associated with the RNA expression of many other genes, with 874 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SHISA3-associated genes across cancer lineages are HKDC1, CCDC117, and GOLGA2P11. Each is linked with SHISA3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SHISA3-to-partner and partner-to-SHISA3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SHISA3 versus HKDC1 in LUAD, with a Pearson correlation of 0.46.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHISA3→partner) and Y-score (partner→SHISA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	HKDC1 →	+1.298	+1.929	.009	.008	3	2
LSCC	CCDC117 →	-0.681	-0.788	.001	<.001	3	2
LUAD	GOLGA2P11 →	+0.879	+1.301	.003	.002	3	2
CCRCC	N4BP1 →	+0.422	+1.285	.004	.004	3	1
CCRCC	BPNT2 →	+0.639	+1.197	.008	.002	3	1
CCRCC	ERI1 →	+0.371	+1.353	.007	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 874 associations by consensus.

SHISA3 vs HKDC1 — LUAD

Explore this scatter interactively →