SHISA3

Across TCGA patient cohorts, SHISA3 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SHISA3-associated genes across cancer lineages are INPP4B, MEK1, and P-Cadherin. Each is linked with SHISA3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SHISA3-to-partner and partner-to-SHISA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by SHISA3-low versus SHISA3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHISA3→partner) and Y-score (partner→SHISA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.383	-3.169	.018	.018	3	1
UCEC	MEK1 →	+0.583	+3.321	.001	.010	3	1
UCEC	P-Cadherin →	-0.165	-2.308	.023	.036	3	1
UCEC	PCNA →	+0.309	+3.169	.004	.018	3	1
UCEC	Rictor_pT1135 →	-0.157	-3.459	.002	.005	3	1
UCEC	ATM →	-0.913	-3.459	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

INPP4B by SHISA3 expression — UCEC

Explore this box plot interactively →