SHISA3

Across TCGA cell cohorts, SHISA3 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,237 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SHISA3-associated GO terms across cancer lineages are Spliceosome-depend formation of circular RNA, Negative regulation of mitotic cell cycle phase transition, and RNA splicing, via transesterification reactions. Each is linked with SHISA3 in more than 5 cancer types. Because this analysis shows association rather than direction, both SHISA3-to-partner and partner-to-SHISA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Spliceosome-depend formation of circular RNA grouped by SHISA3-low versus SHISA3-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SHISA3→partner) and Y-score (partner→SHISA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Spliceosome-depend formation of circular RNA →	+0.201	+0.399	.002	.004	3	6
BLOOD_Lymphoma	Negative regulation of mitotic cell cycle phase transition →	+0.053	+0.613	<.001	.002	3	5
BLOOD_Lymphoma	RNA splicing, via transesterification reactions →	+0.067	+0.853	<.001	.001	3	5
SOFT_TISSUE	Positive regulation of stress fiber assembly →	+0.092	+1.247	<.001	.007	3	5
BLOOD_Lymphoma	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile →	+0.066	+0.852	<.001	.001	3	5
BLOOD_Lymphoma	mRNA splicing, via spliceosome →	+0.066	+0.852	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,237 associations by consensus.

Spliceosome-depend formation of circular RNA by SHISA3 expression — LUNG_SCLC

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