SHISA3

Across TCGA cell cohorts, SHISA3 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SHISA3-associated genes across cancer lineages are VAX1, SDR9C7, and BPIFA1. Each is linked with SHISA3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SHISA3-to-partner and partner-to-SHISA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VAX1 grouped by SHISA3-low versus SHISA3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHISA3→partner) and Y-score (partner→SHISA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	VAX1 →	+0.744	+3.519	<.001	.007	3	1
LARGE_INTESTINE	SDR9C7 →	+0.099	+3.333	.009	.009	3	1
LARGE_INTESTINE	BPIFA1 →	+0.174	+3.103	<.001	.004	3	1
LARGE_INTESTINE	PRAMEF20 →	+0.008	+3.700	<.001	.009	3	1
LARGE_INTESTINE	TECRL →	+0.012	+3.562	<.001	.002	3	1
LARGE_INTESTINE	LINGO4 →	+0.166	+3.869	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

VAX1 by SHISA3 expression — LARGE_INTESTINE

Explore this box plot interactively →