SHISA2

Across TCGA patient cohorts, SHISA2 RNA expression is significantly associated with the protein abundance of many other proteins, with 14,441 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible SHISA2-associated proteins across cancer lineages are PDLIM4, FBLN1, and GSN. Each is linked with SHISA2 in more than 6 cancer types. Because this analysis shows association rather than direction, both SHISA2-to-partner and partner-to-SHISA2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SHISA2 versus PDLIM4 in CCRCC, with a Pearson correlation of 0.29.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SHISA2→partner) and Y-score (partner→SHISA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	PDLIM4 →	+0.776	+0.740	<.001	<.001	3	7
OV	FBLN1 →	+0.897	+1.045	<.001	<.001	3	7
GBM	GSN →	+0.769	+0.774	<.001	<.001	3	7
BRCA	OLFML3 →	+1.012	+1.922	<.001	<.001	3	6
OV	PALLD →	+0.786	+0.958	<.001	<.001	3	6
OV	CSRP2 →	+0.738	+1.032	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,441 associations by consensus.

SHISA2 vs PDLIM4 — CCRCC

Explore this scatter interactively →