SHISA2

Across TCGA cell cohorts, SHISA2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,122 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SHISA2-associated GO terms across cancer lineages are Regulation of syncytium formation by plasma membrane fusion, Mitochondrial electron transport, cytochrome c to oxygen, and Sister chromatid cohesion. Each is linked with SHISA2 in more than 6 cancer types. Because this analysis shows association rather than direction, both SHISA2-to-partner and partner-to-SHISA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of syncytium formation by plasma membrane fusion grouped by SHISA2-low versus SHISA2-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SHISA2→partner) and Y-score (partner→SHISA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Regulation of syncytium formation by plasma membrane fusion →	+0.061	+2.902	<.001	<.001	3	7
SOFT_TISSUE	Mitochondrial electron transport, cytochrome c to oxygen →	+0.066	+3.115	<.001	<.001	3	7
LUNG_SCLC	Sister chromatid cohesion →	+0.110	+2.706	<.001	<.001	3	7
LIVER	Nucleus organization →	+0.064	+2.465	<.001	<.001	3	7
LUNG_SCLC	Vesicle fusion →	+0.051	+1.773	<.001	.005	3	7
SKIN	DNA damage tolerance →	+0.060	+1.636	.001	.005	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,122 associations by consensus.

Regulation of syncytium formation by plasma membrane fusion by SHISA2 expression — SOFT_TISSUE

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