SHH

Across TCGA patient cohorts, SHH protein abundance is significantly associated with the RNA expression of many other genes, with 718 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SHH-associated genes across cancer lineages are RPS17P1, PLEKHA4, and ICAM2. Each is linked with SHH in more than 1 cancer types. Because this analysis shows association rather than direction, both SHH-to-partner and partner-to-SHH results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SHH versus RPS17P1 in LSCC, with a Pearson correlation of 0.53.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHH→partner) and Y-score (partner→SHH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RPS17P1 →	+0.793	+1.125	.008	.003	3	2
LUAD	PLEKHA4 →	+0.939	+0.704	.004	.004	3	1
LUAD	ICAM2 →	+0.936	+0.790	<.001	<.001	3	1
LUAD	SLC27A6 →	+0.279	+0.805	<.001	.001	3	1
LUAD	PNRC1 →	+1.075	+0.790	.004	<.001	3	1
LUAD	IL34 →	+1.176	+0.777	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 718 associations by consensus.

SHH vs RPS17P1 — LSCC

Explore this scatter interactively →