SHH

Across TCGA patient cohorts, SHH protein abundance is significantly associated with the protein abundance of many other proteins, with 822 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SHH-associated proteins across cancer lineages are TRAC, SIT1_S182, and SNX6_S194. Each is linked with SHH in more than 1 cancer types. Because this analysis shows association rather than direction, both SHH-to-partner and partner-to-SHH results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SHH versus TRAC in LSCC, with a Pearson correlation of 0.53.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SHH→partner) and Y-score (partner→SHH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TRAC →	+1.250	+0.912	.001	.003	3	2
LSCC	SIT1_S182 →	+0.742	+0.980	.009	.004	3	1
LSCC	SNX6_S194 →	+0.564	+0.962	.003	.002	3	1
LSCC	ADIRF →	+0.576	+0.944	.004	.002	3	1
LSCC	MYO5C →	+0.812	+1.215	.002	.007	3	1
LSCC	PHLDB1_S664 →	+1.114	+1.105	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 822 associations by consensus.

SHH vs TRAC — LSCC

Explore this scatter interactively →