SHH

Across TCGA patient cohorts, SHH mutation is significantly associated with the RNA expression of many other genes, with 2,224 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SHH-associated genes across cancer lineages are RN7SL623P, SNORD114-11, and H2AC16. Each is linked with SHH in more than 2 cancer types. Because this analysis shows association rather than direction, both SHH-to-partner and partner-to-SHH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL623P grouped by SHH-low versus SHH-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHH→partner) and Y-score (partner→SHH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RN7SL623P →	+0.188	+3.670	.007	.002	3	3
COAD	SNORD114-11 →	+0.738	+4.920	<.001	<.001	3	3
UCEC	H2AC16 →	+0.534	+2.156	.003	.009	3	2
UCEC	ESS2 →	+0.369	+2.595	<.001	<.001	3	2
UCEC	ADNP2 →	+0.636	+2.947	<.001	<.001	3	2
UCEC	LPIN1 →	+0.441	+2.823	.005	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,224 associations by consensus.

RN7SL623P by SHH expression — COAD

Explore this box plot interactively →