SHH

Across TCGA patient cohorts, SHH mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SHH-associated genes across cancer lineages are ATM, JNK_pT183_Y185, and mTOR_pS2448. Each is linked with SHH in more than 2 cancer types. Because this analysis shows association rather than direction, both SHH-to-partner and partner-to-SHH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by SHH-low versus SHH-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHH→partner) and Y-score (partner→SHH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ATM →	-0.752	-3.161	<.001	.019	3	3
UCEC	JNK_pT183_Y185 →	-0.231	-3.700	<.001	.001	3	2
UCEC	mTOR_pS2448 →	-0.185	-3.446	.002	.005	3	2
COAD	PKC-b-II_pS660 →	-0.563	-3.000	.001	.034	3	2
UCEC	Annexin-1 →	+0.570	+3.189	.008	.010	3	2
UCEC	Smad3 →	+0.128	+2.999	.039	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

ATM by SHH expression — COAD

Explore this box plot interactively →