SHH

Across TCGA cell cohorts, SHH RNA expression is significantly associated with the go_rna of many other GO terms, with 2,360 significant associations in total. STOMACH shows the largest number of these associations.

The most reproducible SHH-associated GO terms across cancer lineages are Negative regulation of dopaminergic neuron differentiation, Kidney mesenchymal cell proliferation, and Metanephric mesenchymal cell proliferation involved in metanephros development. Each is linked with SHH in more than 10 cancer types. Because this analysis shows association rather than direction, both SHH-to-partner and partner-to-SHH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of dopaminergic neuron differentiation grouped by SHH-low versus SHH-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SHH→partner) and Y-score (partner→SHH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Negative regulation of dopaminergic neuron differentiation →	-0.282	-1.103	<.001	<.001	3	11
LIVER	Kidney mesenchymal cell proliferation →	-0.403	-2.260	<.001	<.001	2	11
LIVER	Metanephric mesenchymal cell proliferation involved in metanephros development →	-0.403	-2.260	<.001	<.001	2	11
LARGE_INTESTINE	Regulation of nodal signaling pathway →	-0.223	-1.134	<.001	<.001	3	8
KIDNEY	Regulation of adaptive immune response →	+0.055	+1.440	.001	<.001	3	6
STOMACH	Tissue homeostasis →	+0.052	+1.198	.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,360 associations by consensus.

Negative regulation of dopaminergic neuron differentiation by SHH expression — OVARY

Explore this box plot interactively →