SHH

Across TCGA cell cohorts, SHH mutation is significantly associated with the RNA expression of many other genes, with 32 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SHH-associated genes across cancer lineages are AVP, KRTAP4-1, and FGFBP2. Each is linked with SHH in more than 1 cancer types. Because this analysis shows association rather than direction, both SHH-to-partner and partner-to-SHH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AVP grouped by SHH-low versus SHH-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHH→partner) and Y-score (partner→SHH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	AVP →	+0.031	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	KRTAP4-1 →	+0.179	+4.867	<.001	.009	3	1
LARGE_INTESTINE	FGFBP2 →	+1.864	+3.254	<.001	.007	3	1
LARGE_INTESTINE	TKTL2 →	+0.037	+3.187	.002	.006	3	1
LARGE_INTESTINE	MS4A7 →	+0.048	+3.942	<.001	.001	3	1
LARGE_INTESTINE	SCARA5 →	+0.287	+3.667	.007	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

AVP by SHH expression — BLOOD_Lymphoma

Explore this box plot interactively →