SHFL

Across TCGA pan-cancer cohorts, SHFL mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SHFL data layer compared with 25 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher SHFL mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SHFL expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

UCEC, LUAD, and PDAC are the cancer types where SHFL mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	III,IV	0.433	1.000	.007	40	view →
LUAD	DFS	Median	All	0.779	0.468	<.001	17	view →
PDAC	OS	Median	IV	0.951	0.381	.006	6	view →
LSCC	DFS	Median	II,III,IV	0.531	0.787	.027	3	view →
CCRCC	DFS	Tertile	All	0.699	0.851	.042	2	view →
GBM	OS	Quartile	All	0.592	0.882	.039	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SHFL–UCEC (OS)

Open the UCEC breakdown →