SHFL

Across TCGA patient cohorts, SHFL protein abundance is significantly associated with the RNA expression of many other genes, with 15,008 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SHFL-associated genes across cancer lineages are SERPING1, TRIM22, and RSAD2. Each is linked with SHFL in more than 8 cancer types. Because this analysis shows association rather than direction, both SHFL-to-partner and partner-to-SHFL results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SHFL versus SERPING1 in OV, with a Pearson correlation of 0.40.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHFL→partner) and Y-score (partner→SHFL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SERPING1 →	+1.181	+0.391	<.001	.001	3	9
HNSC	TRIM22 →	+1.221	+0.350	<.001	<.001	3	8
OV	RSAD2 →	+1.469	+0.424	<.001	<.001	3	8
COAD	APOBEC3G →	+0.785	+0.226	<.001	.001	3	8
HNSC	OAS2 →	+1.568	+0.401	<.001	<.001	3	7
HNSC	IFIT3 →	+1.845	+0.306	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,008 associations by consensus.

SHFL vs SERPING1 — OV

Explore this scatter interactively →