SHFL

Across TCGA patient cohorts, SHFL mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SHFL-associated genes across cancer lineages are FoxM1, Lck, and VHL. Each is linked with SHFL in more than 1 cancer types. Because this analysis shows association rather than direction, both SHFL-to-partner and partner-to-SHFL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by SHFL-low versus SHFL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHFL→partner) and Y-score (partner→SHFL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.258	+3.459	.047	.005	3	1
UCEC	Lck →	-0.246	-3.000	.014	.036	3	1
UCEC	VHL →	-1.004	-3.459	.003	.005	3	1
UCEC	Caspase-8 →	-0.308	-3.143	.014	.018	3	1
UCEC	INPP4B →	-0.334	-3.000	.040	.036	2	1
UCEC	p62 Lck ligand →	+0.501	+3.179	.002	.010	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

FoxM1 by SHFL expression — UCEC

Explore this box plot interactively →