SHFL

Across TCGA cell cohorts, SHFL RNA expression is significantly associated with the RNA expression of many other genes, with 10,337 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SHFL-associated genes across cancer lineages are DHX58, HELZ2, and IFI6. Each is linked with SHFL in more than 18 cancer types. Because this analysis shows association rather than direction, both SHFL-to-partner and partner-to-SHFL results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SHFL versus DHX58 in UPPER_AERODIGESTIVE_TRACT, with a Pearson correlation of 0.82.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHFL→partner) and Y-score (partner→SHFL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	DHX58 →	+2.065	+1.391	<.001	<.001	3	19
SOFT_TISSUE	HELZ2 →	+2.049	+2.488	<.001	<.001	3	19
KIDNEY	IFI6 →	+4.175	+1.553	<.001	<.001	3	17
BLOOD_Lymphoma	PARP14 →	+2.261	+1.211	<.001	<.001	3	16
LIVER	PARP10 →	+2.019	+1.706	.001	.003	2	17
SOFT_TISSUE	IFI35 →	+2.642	+1.999	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,337 associations by consensus.

SHFL vs DHX58 — UPPER_AERODIGESTIVE_TRACT

Explore this scatter interactively →