SHFL

Across TCGA cell cohorts, SHFL mutation is significantly associated with the RNA expression of many other genes, with 613 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SHFL-associated genes across cancer lineages are GGA1, GCAT, and ANKRD54. Each is linked with SHFL in more than 1 cancer types. Because this analysis shows association rather than direction, both SHFL-to-partner and partner-to-SHFL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GGA1 grouped by SHFL-low versus SHFL-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHFL→partner) and Y-score (partner→SHFL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GGA1 →	+0.662	+3.169	.002	.009	3	1
LARGE_INTESTINE	GCAT →	+1.425	+3.364	<.001	.002	3	1
LARGE_INTESTINE	ANKRD54 →	+0.524	+3.451	.002	.002	3	1
LARGE_INTESTINE	CCDC134 →	+0.898	+3.364	<.001	.002	3	1
LARGE_INTESTINE	DEPDC5 →	+0.691	+3.364	<.001	.002	3	1
LARGE_INTESTINE	CENPM →	+0.965	+3.364	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 613 associations by consensus.

GGA1 by SHFL expression — LARGE_INTESTINE

Explore this box plot interactively →