SHE

Across TCGA patient cohorts, SHE mutation is significantly associated with the RNA expression of many other genes, with 1,430 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SHE-associated genes across cancer lineages are RN7SL341P, MIR6737, and TAF9. Each is linked with SHE in more than 1 cancer types. Because this analysis shows association rather than direction, both SHE-to-partner and partner-to-SHE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL341P grouped by SHE-low versus SHE-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHE→partner) and Y-score (partner→SHE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RN7SL341P →	+0.101	+5.064	<.001	.004	3	2
BRCA	MIR6737 →	+0.388	+4.506	<.001	.009	3	2
UCEC	TAF9 →	+0.751	+3.480	<.001	.002	3	2
CESC	LINC02559 →	+1.780	+6.342	<.001	.001	3	2
LUAD	RNA5SP38 →	+1.280	+5.044	<.001	.009	3	2
LUAD	RNU6-162P →	+0.335	+6.912	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,430 associations by consensus.

RN7SL341P by SHE expression — BRCA

Explore this box plot interactively →