SHE

Across TCGA patient cohorts, SHE mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SHE-associated genes across cancer lineages are ASNS, ATM, and 4E-BP1. Each is linked with SHE in more than 1 cancer types. Because this analysis shows association rather than direction, both SHE-to-partner and partner-to-SHE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by SHE-low versus SHE-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHE→partner) and Y-score (partner→SHE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.389	+3.169	.025	.019	3	2
UCEC	ATM →	-0.540	-2.986	.013	.035	3	2
UCEC	4E-BP1 →	+0.286	+3.029	.028	.018	3	2
UCEC	C-Raf →	+0.161	+3.169	.020	.019	3	2
SKCM	PCNA →	+0.311	+3.169	.003	.019	3	2
UCEC	ERK2 →	+0.331	+3.321	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

ASNS by SHE expression — UCEC

Explore this box plot interactively →