SHE

Across TCGA cell cohorts, SHE mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible SHE-associated genes across cancer lineages are OR2D3, IL2, and LCE2B. Each is linked with SHE in more than 1 cancer types. Because this analysis shows association rather than direction, both SHE-to-partner and partner-to-SHE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2D3 grouped by SHE-low versus SHE-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHE→partner) and Y-score (partner→SHE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR2D3 →	+0.027	+4.095	.001	.009	3	1
OVARY	IL2 →	+0.042	+5.196	<.001	.005	3	1
OVARY	LCE2B →	+0.040	+5.196	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

OR2D3 by SHE expression — LARGE_INTESTINE

Explore this box plot interactively →