SHCBP1

Across TCGA pan-cancer cohorts, SHCBP1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SHCBP1 data layer compared with 24 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SHCBP1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated SHCBP1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

HNSC, LUAD, and LSCC are the cancer types where SHCBP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.963	0.764	.003	34	view →
LUAD	OS	Quartile	II,III,IV	0.242	0.740	.012	9	view →
LSCC	DFS	Median	III,IV	0.632	0.932	.011	4	view →
UCEC	OS	Median	All	1.000	0.859	.020	2	view →
PDAC	OS	Quartile	All	0.772	1.000	.012	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SHCBP1–HNSC (OS)

Open the HNSC breakdown →