SHCBP1

Across TCGA patient cohorts, SHCBP1 mutation is significantly associated with the RNA expression of many other genes, with 1,359 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SHCBP1-associated genes across cancer lineages are SNORA70J, CPSF1P2, and C2orf69P4. Each is linked with SHCBP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SHCBP1-to-partner and partner-to-SHCBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNORA70J grouped by SHCBP1-low versus SHCBP1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHCBP1→partner) and Y-score (partner→SHCBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SNORA70J →	+0.451	+5.217	<.001	.007	3	2
LUAD	CPSF1P2 →	+0.102	+5.631	<.001	.004	3	2
LUAD	C2orf69P4 →	+0.105	+7.599	<.001	<.001	3	2
SKCM	RNU6-634P →	+0.147	+4.408	<.001	.005	3	2
SKCM	RN7SL727P →	+0.068	+4.634	<.001	.003	3	2
UCEC	MIR4518 →	+0.493	+1.726	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,359 associations by consensus.

SNORA70J by SHCBP1 expression — LUAD

Explore this box plot interactively →