SHCBP1

Across TCGA patient cohorts, SHCBP1 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SHCBP1-associated genes across cancer lineages are EGFR_pY1068, STAT3_pY705, and ASNS. Each is linked with SHCBP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SHCBP1-to-partner and partner-to-SHCBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by SHCBP1-low versus SHCBP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHCBP1→partner) and Y-score (partner→SHCBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.219	-1.678	.022	.023	3	2
UCEC	STAT3_pY705 →	-0.265	-1.690	.008	.042	3	2
UCEC	ASNS →	+0.528	+2.807	<.001	.003	3	2
UCEC	IGFBP2 →	-0.613	-1.678	.013	.023	3	1
UCEC	Ku80 →	+0.237	+2.100	.008	.003	3	1
UCEC	p62 Lck ligand →	+0.359	+2.700	.003	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

EGFR_pY1068 by SHCBP1 expression — UCEC

Explore this box plot interactively →