SHCBP1

Across TCGA cell cohorts, SHCBP1 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible SHCBP1-associated genes across cancer lineages are KRTAP21-2, NKX2-6, and FAM24A. Each is linked with SHCBP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SHCBP1-to-partner and partner-to-SHCBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP21-2 grouped by SHCBP1-low versus SHCBP1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHCBP1→partner) and Y-score (partner→SHCBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	KRTAP21-2 →	+0.085	+5.539	<.001	.003	3	2
BLOOD_Leukemia	NKX2-6 →	+0.663	+5.201	<.001	.006	3	1
BLOOD_Leukemia	FAM24A →	+0.082	+5.969	<.001	.001	3	1
BLOOD_Leukemia	IQCF5 →	+0.135	+5.201	<.001	.006	3	1
UPPER_AERODIGESTIVE_TRACT	EDN3 →	+0.082	+4.209	<.001	.006	3	1
UPPER_AERODIGESTIVE_TRACT	BHLHE23 →	+0.032	+4.357	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

KRTAP21-2 by SHCBP1 expression — BLOOD_Leukemia

Explore this box plot interactively →